Encountering unpredicted off-target effects of pharmacological inhibitors
نویسندگان
چکیده
منابع مشابه
Encountering unpredicted off-target effects of pharmacological inhibitors.
With the emergence of chemical biology, the use of pharmacological inhibitors in biological research has been expanding. SP600125 is a low-molecular weight compound that has been widely used to inhibit c-Jun-N-terminal kinase (JNK). A recent publication by Tanemura et al. (J. Biochem. 145:345-354, 2009) indicated that SP600125 also inhibits phosphatidylinositol 3-kinase (PI3K) in an isoform-sel...
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ژورنال
عنوان ژورنال: Journal of Biochemistry
سال: 2011
ISSN: 0021-924X
DOI: 10.1093/jb/mvr053